Relapse Prevention in
Depression and Anxiety
Relapse is a common challenge for individuals who have recovered from depression and anxiety. To address this, our lab is dedicated to advancing evidence-based interventions for relapse prevention. We are committed not only to promoting well-proven methods but also to exploring innovative approaches that can expand access to care. This includes promoting low-cost interventions, leveraging technology, and expanding non-specialist care in both high- and low-income countries. Below, you'll find a selection of initiatives and ongoing studies our lab has led to support these efforts.
-
Besten, M. E., van Vugt, M., Riese, H., Bockting, C. L., Ostafin, B. D., Aleman, A., & van Tol, M.-J. (2024). Understanding mechanisms of depression prevention: Study protocol of a randomized cross-over trial to investigate mechanisms of mindfulness and positive fantasizing as intervention techniques for reducing perseverative cognition in remitted depressed individuals. BMC Psychiatry, 24(1), 141. https://doi.org/10.1186/s12888-024-05592-8
Breedvelt, J. J. F., Karyotaki, E., Warren, F. C., Brouwer, M. E., Jermann, F., Hollandare, F., Klein, N., de Jonge, M., Klein, D. N., Farb, N., Segal, Z., Biesheuvel Leliefeld, K. E. M., Jarrett, R., Vittengl, J., Thase, M., Ma, H., Kuyken, W., Shallcross, A. J., van Heeringen, C., … Bockting, C. L. (2024). An individual participant data meta-analysis of psychological interventions for preventing depression relapse. Nature Mental Health, 2(2), 154–163. https://doi.org/10.1038/s44220-023-00178-x
Kooiman, B. E., Robberegt, S. J., Albers, C. J., Bockting, C. L., Stikkelbroek, Y. A., & Nauta, M. H. (2023). Congruency of multimodal data-driven personalization with shared decision-making for StayFine: individualized app-based relapse prevention for anxiety and depression in young people. Frontiers in psychiatry, 14, 1229713. https://doi.org/10.3389/fpsyt.2023.1229713
Robberegt, S. J., Brouwer, M. E., Kooiman, B. E., Stikkelbroek, Y. A., Nauta, M. H., & Bockting, C. L. (2023). Meta-analysis: Relapse prevention strategies for depression and anxiety in remitted adolescents and young adults. Journal of the American Academy of Child & Adolescent Psychiatry, 62(3), 306-317. https://doi.org/10.1016/j.jaac.2022.04.014
Robberegt, S. J., Kooiman, B. E. A. M., Albers, C. J., Nauta, M. H., Bockting, C. L., & Stikkelbroek, Y. (2023). Personalised app-based relapse prevention of depressive and anxiety disorders in remitted adolescents and young adults: a protocol of the StayFine RCT. BMJ Open 2022; 12:e058560. https://doi.org10.1136/bmjopen-2021-058560
Teijema, J. J., Hofstee, L., Brouwer, M., de Bruin, J., Ferdinands, G., de Boer, J., Vizan, P., van den Brand, S., Bockting, C. L., van de Schoot, R., & Bagheri, A. (2023). Active learning-based systematic reviewing using switching classification models: The case of the onset, maintenance, and relapse of depressive disorders. Frontiers in Research Metrics and Analytics, 8, 1178181. https://doi.org/10.3389/frma.2023.1178181
van Kleef, R., Kaushik, P., Besten, M., Marsman, J., Bockting, C. L., van Vugt, M., Aleman, A., van Tol, M. (2023). Understanding and predicting future relapse in depression from resting state functional connectivity and self-referential processing. Journal of Psychiatric Research, 165, 305-314. https://doi.org/10.1016/j.jpsychires.2023.07.034
Heuschen, C. B., Mocking, R. J., Zantvoord, J. B., Figueroa, C. A., Schene, A. H., Denys, D. A., Ruhé, H. G., Bockting, C. L., & Lok, A. (2022). Suicidal ideation in remitted major depressive disorder predicts recurrence. Journal of Psychiatric Research, 151, 65–72. https://doi.org/10.1016/j.jpsychires.2022.04.005
Breedvelt, J., Brouwer, M. E., Harrer, M., Semkovska, M., Ebert, D. D., Cuijpers, P., & Bockting, C. L. (2021). Psychological interventions as an alternative and add-on to antidepressant medication to prevent depressive relapse: Systematic review and meta-analysis. The British Journal of Psychiatry :The Journal of Mental Science, 219(4), 538–545. https://doi.org/10.1192/bjp.2020.198
Van Tol, M. J., Eike, R., Van Kleef, R., Marsman, J. B., Van Valen, E., Aleman, A., & Bockting, C. L. (2020). P.348 Understanding neurocognitive working mechanisms of relapse prevention – the role of emotion regulation in remitted major depressive disorder. European Neuropsychopharmacology, 40, S202-S203. https://doi.org/10.1016/j.euroneuro.2020.09.264
Brouwer, M. E., Williams, A. D., Forand, N. R., DeRubeis, R. J., & Bockting, C. L. (2019). Dysfunctional attitudes or extreme response style as predictors of depressive relapse and recurrence after mobile cognitive therapy for recurrent depression. Journal of Affective Disorders, 243, 48-54. https://doi.org/10.1016/j.jad.2018.09.002
Brouwer, M. E., Williams, A. D., Kennis, M., Fu, Z., Klein, N. S., Cuijpers, P., & Bockting, C. L. (2019). Psychological theories of depressive relapse and recurrence: A systematic review and meta-analysis of prospective studies. Clinical Psychology Review, 74, 101773. https://doi.org/10.1016/j.cpr.2019.101773
Elgersma, H. J., Koster, E. H. W., Vugteveen, J., Hoekzema, A., Penninx, B., Bockting, C. L., & de Jong, P. J. (2019). Predictive value of attentional bias for the recurrence of depression: A 4-year prospective study in remitted depressed individuals. Behaviour Research and Therapy, 114, 25-34. https://doi.org/10.1016/j.brat.2019.01.001
van Kleef, R. S., Bockting, C. L., van Valen, E., Aleman, A., Marsman, J. C., & van Tol, M. J. (2019). Neurocognitive working mechanisms of the prevention of relapse in remitted recurrent depression (NEWPRIDE): Protocol of a randomized controlled neuroimaging trial of preventive cognitive therapy. BMC Psychiatry, 19(1), 409. https://doi.org/10.1186/s12888-019-2384-0
Biesheuvel-Leliefeld, K. E. M., Bosmans, J. E., Dijkstra-Kersten, S. M. A., Smit, F., Bockting, C. L., van Schaik, D. J. F., van Marwijk, H., & van der Horst, H. E. (2018). A supported self-help for recurrent depression in primary care; An economic evaluation alongside a multi-center randomised controlled trial. PLOS One, 13(12), e0208570. https://doi.org/10.1371/journal.pone.0208570
Crist, C., de Jonge, M., Bockting, C. L.,Kikkert, M. J., van Schaik, D. J. F., Beekman, A. T. F., & Dekker, J. J. M. (2018). Prevalence and predictors of violent victimization in remitted patients with recurrent depression. Journal of Affective Disorders, 238, 405-411. https://doi.org/10.1016/j.jad.2018.06.019
De Jonge, M., Bockting, C. L., van Oppen, P., Van, H. L., Peen, J., Kikkert, M. J., & Dekker, J. J. M. (2018). The association between the number of previous episodes and modifiable vulnerability factors in remitted patients with recurrent depression. PLOS One, 13(11), e0206495. https://doi.org/10.1371/journal.pone.0206495
Klein, N. S., Kok, G. D., Burger, H., van Valen, E., Riper, H., Cuijpers, P., Dekker, J., Smit, F., van der Heiden, C., & Bockting, C. L. (2018). No sustainable effects of an internet-based relapse prevention program over 24 months in recurrent depression: Primary outcomes of a randomized controlled trial. Psychotherapy and Psychosomatics, 87(1), 55-57. https://doi.org/10.1159/000485039
Slofstra, C., Nauta, M. H., Bringmann, L. F., Klein, N. S., Albers, C. J., Batalas, N., Wicher, M., & Bockting, C. L. (2018). Individual negative affective trajectories can be detected during different depressive relapse prevention strategies. Psychotherapy and Psychosomatics, 87(4), 243-245. https://doi.org/10.1159/000489044
van Tuijl, L. A., Glashouwer, K. A., Elgersma, H. J., Bockting, C. L., Penninx, B., & de Jong, P. J. (2018). Depression recurrence after recovery: Prognostic value of implicit and explicit self-depressed associations. Behaviour Research and Therapy, 107, 76-82. https://doi.org/10.1016/j.brat.2018.06.001
Biesheuvel-Leliefeld. K. E. M., Dijkstra-Kersten, S.M.A. , van Schaik, D.J.F., van Marwijk, H. W. J., Smit, F., van der Horst, H.E., Bockting, C. L. (2017). Effectiveness of supported self-help in recurrent depression: a randomised controlled trial in primary care. Psychotherapy and Psychosomatics, 86(4), 220-230, https://doi.org/10.1159/000472260
Mocking, R. J. T., Figueroa, C. A., Rive, M. M., Geugies, H., Servaas, M. N., Assies, J., Koeter, M. W. J., Vaz, F. M., Wichers, M., van Straalen, J. P., de Raedt, R., Bockting, C. L.,Harmer, C. J., Schene, A. H., & Ruhé, H. G. (2016). Vulnerability for new episodes in recurrent major depressive disorder: protocol for the longitudinal DELTA neuroimaging cohort study. BMJ Open, 6, e009510. https://doi.org/10.1136/bmjopen-2015009510
Biesheuvel-Leliefeld, K. E. M., Kok, G. D., Bockting, C. L.,Cuijpers, P., Hollon, S. D., van Marwijk, H. W. J., & Smit, F. (2015). Effectiveness of psychological interventions in preventing recurrence of depressive disorder: Meta-analysis and meta-regression. Journal of Affective Disorders, 174, 400-410. https://doi.org/10.1016/j.jad.2014.12.016
Bockting, C. L., Hollon, S. D., Kuyken, W., Jarrett. R., & Dobson, K. S. (2015). A lifetime approach to Major Depressive Disorder: The contributions of psychological interventions in preventing relapse and recurrence. Clinical Psychology Review, 41, 16-26. https://doi.org/10.1016/j.cpr.2015.02.003
Elgersma, H. J., de Jong, P. J., van Rijsbergen, G. D., Kok, G. D., Burger, H., van der Does, W., Penninx, B. W., & Bockting, C. L. (2015). Cognitive reactivity, self-depressed associations, and the recurrence of depression. Journal of Affective Disorders, 183, 300-309. https://doi.org/10.1016/j.jad.2015.05.018
Figueroa, C. A., Ruhé, H. G., Koeter, M., Spinhoven, P., van der Does, W., Bockting, C. L.,& Schene, A. H. (2015). Cognitive reactivity versus dysfunctional cognitions and the prediction of relapse in recurrent major depressive disorder. Journal of Clinical Psychiatry, 76, e1306– e1312. https://doi.org/10.4088/JCP.14m09268
Bockting, C. L. (2010). Breaking the rhythm of depression: Cognitive behavior therapy and relapse prevention for depression. Psychological Topics, 19, 273-287.
Ten Doesschate, M. C, Koeter, M., Bockting, C. L., & Schene, A. H. (2009). Health related quality of life in recurrent depression: A comparison with a general population sample. Journal of Affective Disorders 120, 126-32. https://doi.org.10.1016/j.jad.2009.04.026
Preventive Cognitive Therapy (PCT)
Developed by Claudi Bockting, Preventive Cognitive Therapy is an exentensively researched method for relapse prevention in depression. Thoughout 8 sessions, clients and therapeut develop a tailor-made plan to overcome depression relapse. PCT is cost effective, can be used alongside or as an alternative to anti-depressants and has been shown to provide significant protection against relapse over a period of 2 to 20 years. PCT is selected for dissimination via the Ministry of Health and MIND.
-
Books for Clinicians:
Preventieve cognitieve training bij terugkerende depressie.
Auteur: Claudi L. H. Bockting
2009 | ISBN 9789031353071 | 1e druk
Bohn Stafleu van Loghum € 47,95Terapia cognitiva preventiva para la depresión recurrente
Auteur: Claudi L. H. Bockting (adaptado y traducido por Cristian J. Garay & Cristina Tenreyro)
2020 | ISBN 978-98-9875704350 | 1e druk
Liberia Akadia Editorial, € 17,99Self-help Books:
Between dip and dream: Break your patterns, dare to feel.
Authors: Claudi LH Bockting & Evelien van Valen
2013 | ISBN 9789000328857 | 1st edition
Spectrum € 10.00No more depressed.
Author: Claudi LH Bockting
2009 | ISBN 9789031374274 | 1st edition
Bohn Stafleu van Loghum € 23.95 -
de Jonge, M., Blankers, M., Bockting, C. L., van Dijk, M. K., Kikkert, M. J., & Dekker, J. J. M. (2024). Economic evaluation of preventive cognitive therapy versus care as usual in cognitive behavioral therapy responders. Frontiers in Psychiatry, 14, 1134071. https://doi.org/10.3389/fpsyt.2023.1134071
Gülpen, J., Brouwer, M. E., Geurtsen, G. J., van Dis, E. A. M., Denys, D. A. J. P., & Bockting, C. L. (2023). Treatments for partial remission of major depressive disorder: A systematic review and meta-analysis. BMJ Mental Health, 26(1), 1–9. https://doi.org/10.1136/bmjment-2023-300827
Legemaat, A. M., Burger, H., Geurtsen, G. J., Brouwer, M., Spinhoven, P., Denys, D., Bockting, C. L. (2023). Effects up to 20-year follow-up of Preventive Cognitive Therapy in adults remitted from recurrent depression: the DELTA study. Psychotherapy and Psychosomatics, 92(1), 55-64. https://doi.org/10.1159/000527906
Bockting, C. L., Legemaat, A. M., van der Stappen, J., Geurtsen, G. J., Semkovska, M., Burger, H., Bergfeld, I. O., Lous, N., Denys, D., & Brouwer, M. (2022). Augmenting neurocognitive remediation therapy to Preventive Cognitive Therapy for partially remitted depressed patients: protocol of a pragmatic multicentre randomized controlled trial. BMJ open, 12(6), e063407. https://doi.org/10.1136/bmjopen-2022-063407
Bockting, C. L., & Rief, W. (2022). Ambassadors of clinical psychology and psychological treatment. Clinical Psychology in Europe, 4(1), 1-2. https://doi.org/10.32872/cpe.8545
Breedvelt, J., Brouwer, M. E., Harrer, M., Semkovska, M., Ebert, D. D., Cuijpers, P., & Bockting, C. L. (2021). Psychological interventions as an alternative and add-on to antidepressant medication to prevent depressive relapse: Systematic review and meta-analysis. The British Journal of Psychiatry :The Journal of Mental Science, 219(4), 538–545. https://doi.org/10.1192/bjp.2020.198
Breedvelt, J., Warren, F. C., Segal, Z., Kuyken, W., & Bockting, C. L. (2021). Continuation of antidepressants vs sequential psychological interventions to prevent relapse in depression: An individual participant data meta-analysis. JAMA Psychiatry, 78(8), 868–875. https://doi.org/10.1001/jamapsychiatry.2021.0823
Breedvelt, J. J. F., Warren, F. C., Brouwer, M. E., Karyotaki, E., Kuyken, W., Cuijpers, P., van Oppen, P., Gilbody., S. & Bockting, C. L. (2020). Individual participant data (IPD) meta-analysis of psychological relapse prevention interventions versus control for patients in remission from depression: A protocol. BMJ Open, 10(2), e034158. https://doi.org/10.1136/bmjopen-2019-034158
Breedvelt, J. J. F., Zamperoni, V., South, E., Uphoff, E. P., Gilbody, S., Bockting, C. L., Churchill, R., & Kousoulis, A. A. (2020). A systematic review of mental health measurement scales for evaluating the effects of mental health prevention interventions. European Journal of Public Health, 30(3), 510-516. https://doi.org/10.1093/eurpub/ckz233
Brouwer, M. E., Molenaar, N. M., Burger, H., Williams, A. D., Albers, C., Lambregtse-van den Berg, M., & Bockting, C. L. (2020). Tapering antidepressants while receiving digital Preventive Cognitive Therapy during pregnancy: An experience sampling methodology trial. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.574357
Molenaar, N. M., Brouwer, M. E., Burger, H.,
Kamperman, A. M., Bergink, V., Hoogendijk, W. J. G., Williams, A., Bockting, C. L., & Lambregtse-van den Berg, M. P. (2020). Preventive cognitive therapy with antidepressant discontinuation during pregnancy: Results from a randomized controlled trial. Journal of Clinical Psychiatry, 81(4). https://doi.org/10.4088/JCP.19l13099
de Jonge, M., Bockting, C. L., Kikkert, M. J., van Dijk, M. K., van Schaik, D. J. F., Peen, J., Hollon, S., & Dekker, J. J. M. (2019). Preventive cognitive therapy versus care as usual in cognitive behavioral therapy responders: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 87(6), 521-529. https://doi.org/10.1037/ccp0000395
Klein, N. S., Wijnen, B. F. M., Lokkerbol, J., Buskens, E., Elgersma, H. J., van Rijsbergen, G. D., Slofstra, C., Ormel, J., Dekker, J., de Jong, P., & Bockting, C. L. (2019). Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants. BJPsych Open, 5(1), e12. https://doi.org/10.1192/bjo.2018.81
van Dis, E. A. M., van Veen, S. C., Hagenaars, M. A., Batelaan, N. M., Bockting, C. L., van den Heuvel, R. M., Cuijpers, P., Engelhard, I. M. (2019). Long-term outcomes of cognitive behavioral therapy for anxiety-related disorders: A systematic review and meta-analysis. JAMA Psychiatry, 77(3), 265-273. https://doi.org/10.1001/jamapsychiatry.2019.3986
Bockting, C. L., Klein, N. S., Elgersma, H. J., van Rijsbergen, G. D., Slofstra, C., Ormel, J., Buskens, E., Dekker, J., de Jong, P. J., Nolen, W. A., Schene, A. H., Hollon, S. D., Burger, H. (2018). The effectiveness of preventive cognitive therapy while tapering antidepressants compared with maintenance antidepressant treatment and their combination in the prevention of depressive relapse or recurrence (DRD study): A three-arm randomised controlled trial. Lancet Psychiatry, 5(5), 401-410. https://doi.org/10.1016/S2215-0366(18)30100-7
Spinhoven, P., Klein, N., Kennis, M., Cramer, A. O. J., Siegle, G., Cuijpers, P., Ormel, J., Hollon, S., & Bockting, C. L. (2018). The effects of cognitive-behavior therapy for depression on repetitive negative thinking: A meta-analysis. Behaviour Research and Therapy, 106, 71-85. https://doi.org/10.1016/j.brat.2018.04.002
Bennebroek Evertsz', F., Sprangers, M. A. G., Sitnikova, K., Stokkers, P. C. F., Ponsioen, C. Y., Bartelsman, J. F. W. M., van Bodegraven, A. A., Fischer, S., Depla, A. C. T. M., Mallant, R. C., Sanderman, R., Burger, H., & Bockting, C. L. (2017). Effectiveness of cognitive-behavioral therapy on quality of life, anxiety, and depressive symptoms among patients with inflammatory bowel disease: A multicenter randomized controlled trial. Journal of Consulting and Clinical Psychology. 85(9), 918-925. https://doi.org/10.1037/ccp0000227
Molenaar, N. M., Brouwer, M. E., Bockting, C. L., Bonsel, G. J., van der Veere, C. N., Torij, H. W., Hoogendijk, W. J., Duvekot, J. J., Burger, H. & Lambregtse-van den Berg, M. P. (2016). Stop or go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre noninferiority randomized controlled trial. BMC Psychiatry, 16(1), 1. https://doi.org/10.1186/s12888016-0752-6
Bockting, C. L., Smid, N. H., Koeter, M. W., Spinhoven, P., Beck, A. T., & Schene, A. H. (2015). Enduring effects of Preventive Cognitive Therapy in adults remitted from recurrent depression: A 10 year follow-up of a randomized controlled trial. Journal of Affective Disorders, 185, 188–194. https://doi.org/10.1016/j.jad.2015.06.048
Burger, H., Bockting, C. L., Beijers, C., Verbeek, T., Stant, A. D., Ormel, J., Stolk, R. P., de Jonge, P., De Jonge, M., Bockting, C. L., Kikkert, M. J., Bosmans, J. E., & Dekker, J. J. (2015). Preventive Cognitive Therapy versus Treatment as Usual in preventing recurrence of depression: Protocol of a multi-centered randomized controlled trial. BMC Psychiatry, 15(1), 1. https://doi.org/10.1186/s12888-015-0508-8
Bockting, C. L., Spinhoven, P., Wouters, L. F., Koeter, M. W. J, Schene, A. H., & the DELTA study group (2009). Long term effects of preventive cognitive therapy in recurrent depression: A 5.5 years follow-up. Journal of Clinical Psychiatry, 70, 1621-1628. https://doi.org/10.4088/JCP.08m04784
Ten Doesschate, M. C., Bockting, C. L., & Schene, A. H. (2009). Adherence to continuation and maintenance antidepressant use in recurrent depression. Journal of Affective Disorders, 115, 167-170. https://doi.org/10.1016/j.jad.2008.07.011
Ten Doesschate, M. C, Bockting, C. L., Koeter, M. W. J., & Schene, A. H. (2009). Predictors of non-adherence to continuation and maintenance antidepressant treatment in recurrent depression. Journal of Clinical Psychiatry, 70, 63-69. https://doi.org/10.4088/jcp.08m04119
Bockting, C. L., Spinhoven, Ph., Koeter, M. W. J., Wouters, L. F., Schene, A. H., & the DELTA study group. (2006). Prediction of recurrence in recurrent depression and the influence of consecutive episodes on vulnerability: A 2-year prospective study. Journal of Clinical Psychiatry, 67, 747-755. https://doi.org/10.4088/JCP.v67n0508
Bockting, C. L., Spinhoven, P., Koeter, M. W. J., Wouters, L. F., Visser, I., Schene, A. H., & the DELTA study group. (2006). Differential predictors of response to preventive cognitive therapy in recurrent depression: A 2-year prospective study.
Bockting, C. L., Schene, A. H., Spinhoven, P., Koeter, M. W. J., Wouters, L. F., Huyser, J., & Kamphuis, J. H. (2005). Preventing relapse/recurrence in recurrent depression using cognitive therapy. Journal of Consulting and Clinical Psychology, 73, 647-657. https://doi.org/10.1037/0022-006X.73.4.647
ITFRA Consortium
ITFRA (International TaskForce for RelApse prevention of depression and anxiety) is a research taskforce co-ordinated by Josefien Breedvelt and Claudi Bockting, that aims to improve our understanding of the prevention of relapse in depression, harmonize outcome and moderator measurement, and advocate for improved outcomes for people who have experienced depression. The current projects are largely focused on individual participant data meta-analysis and meta-analyses aiming to identify what works for whom and evaluate treatment approaches such as the role of psychological interventions and antidepressants in preventing relapse or recurrence.
-
Gülpen, J., Breedvelt, J. J.F., van Dis, E. A.M., Geurtsen, G. J., Warren, F. C., van Heeringen, C., Hitchcock, C., Holländare, F., Huijbers, M. J., Jarrett, R. B., Jermann, F., de Jonge, M., Klein, D. N., Klein, N. S., Ma, S.H., Moore, M. T., Denys, D. A.J.P., Williams, J.M. G., Kuyken, W., & Bockting, C. L. (2025). Psychological interventions for preventing relapse in individuals with partial remission of depression: a systematic review and individual participant data meta-analysis. Psychological Medicine, 55, 1–11. https://doi.org/10.1017/S0033291725000157
Breedvelt, J. J. F., Karyotaki, E., Warren, F. C., Brouwer, M. E., Jermann, F., Hollandare, F., Klein, N., de Jonge, M., Klein, D. N., Farb, N., Segal, Z., Biesheuvel Leliefeld, K. E. M., Jarrett, R., Vittengl, J., Thase, M., Ma, H., Kuyken, W., Shallcross, A. J., van Heeringen, C., … Bockting, C. L. (2024). An individual participant data meta-analysis of psychological interventions for preventing depression relapse. Nature Mental Health, 2(2), 154–163. https://doi.org/10.1038/s44220-023-00178-x
Breedvelt, J., Warren, F. C., Segal, Z., Kuyken, W., & Bockting, C. L. (2021). Continuation of antidepressants vs sequential psychological interventions to prevent relapse in depression: An individual participant data meta-analysis. JAMA Psychiatry, 78(8), 868–875. https://doi.org/10.1001/jamapsychiatry.2021.0823
Breedvelt, J. J. F., Warren, F. C., Brouwer, M. E., Karyotaki, E., Kuyken, W., Cuijpers, P., van Oppen, P., Gilbody., S. & Bockting, C. L. (2020). Individual participant data (IPD) meta-analysis of psychological relapse prevention interventions versus control for patients in remission from depression: A protocol. BMJ Open, 10(2), e034158. https://doi.org/10.1136/bmjopen-2019-034158
Breedvelt, J. J. F., Zamperoni, V., South, E., Uphoff, E. P., Gilbody, S., Bockting, C. L., Churchill, R., & Kousoulis, A. A. (2020). A systematic review of mental health measurement scales for evaluating the effects of mental health prevention interventions. European Journal of Public Health, 30(3), 510-516. https://doi.org/10.1093/eurpub/ckz233
Ongoing Studies
STAYFINE-App: Relapse Prevention in Adolescents
More than one in five adolescents has to deal with anxiety or a depressive disorder before the age of 21. Even after recovery, the prevalence of relapse is especially high in this age group. To investigate whether it is possible to prevent relapse through ongoing monitoring and momentary app-based interventions, we are conducting a randomized controlled trial evaluating the effectiveness of personalized combination of app-based interventions with guidance of loved experience experts. This project is conducted with funding from ZonMw.
MINDCOG: Understanding mechanisms of depression prevention
MINDCOG is a randomized cross-over trial to investigate mechanisms of mindfulness and positive fantasizing (ingredient of PCT) as intervention techniques for reducing perseverative cognition (PC) in remitted depressed individuals. The current study aims to 1) test whether momentary psychological and psychophysiological indices of PC are differentially affected by positive fantasizing versus mindfulness-based interventions, 2) test whether the mechanisms of change by which fantasizing and mindfulness affect PC differ between remitted Major Depressive Disorder versus never-depressed individuals, and 3) explore potential moderators of the main effects of the two interventions (i.e., what works for whom).
HERSTEL: Innovative depression treatment for lasting recovery
Patients partially remitted from depression are at increased risk of relapse. In the HERSTEL-study (eng. RECOVERY), we aim to further reduce depressive symptoms and the risk of relapse using multilevel interventions. To attain this goal, we compare the efficacy of Preventive Cognitive Therapy combined with a serious computer game intervention that targets cognitive functioning to Preventive Cognitive Therapy alone. This project is conducted with funding from the Hersenstichting.