Common Mental Health Conditions

In the Intervention Lab we use a complex systems approach to mental health research. We study interaction of affective, psychological, neurobiological mechanisms and environmental factors that contribute to onset, maintenance and relapse in depression, suicidality and anxiety.

Complex Systems

Together with the Centre for Urban Mental Health and the Institute of Advanced Studies (IAS), our lab applies complex system models to the study of common mental health disorders.

  • Scheffer, M., Bockting, C. L., Borsboom, D., Cools, R., Delecroix, C., Hartmann, J. A., Kendler, K. S., van de Leemput, I., van der Maas, H. L. J., van Nes, E., Mattson, M., McGorry, P. D., & Nelson, B. (2024). A dynamical systems view of psychiatric disorders—Practical implications: A review. JAMA Psychiatry, 81(6):624-630. https://doi.org/10.1001/jamapsychiatry.2024.0228

    Scheffer, M., Bockting, C. L., Borsboom, D., Cools, R., Delecroix, C., Hartmann, J. A., Kendler, K. S., van de Leemput, I., van der Maas, H. L. J., van Nes, E., Mattson, M., McGorry, P. D., & Nelson, B. (2024). A dynamical systems view of psychiatric disorders—Theory: A review. JAMA Psychiatry., 81(6):618-623 https://doi.org/10.1001/jamapsychiatry.2024.0215

    Franzoi, D., Bockting, C. L., Bennett, K. F., Odom, A., Lucassen, P. J., Pathania, A., Lee, A., Brouwer, M. E., van de Schoot, R., Wiers, R. W., & Breedvelt, J. J. F. (2024). Which individual, social, and urban factors in early childhood predict psychopathology in later childhood, adolescence and young adulthood? A systematic review. SSM - Population Health, 25, 101575. https://doi.org/10.1016/j.ssmph.2023.101575

    van der Wal, J. M., van Borkulo, C. D., Haslbeck, J. M. B., Slofstra, C., Klein, N. S., Blanken, T. F., Deserno, M. K., Lok, A., Nauta, M. H., & Bockting, C. L. (2023). Differential impact of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment on affect fluctuations and individual affect networks and impact on relapse: A secondary analysis of a randomised controlled trial. eClinicalMedicine, 66, 102329. https://doi.org/10.1016/j.eclinm.2023.102329

    Bringmann, L. F., Albers, C., Bockting, C. L., Borsboom, D., Ceulemans, E., Cramer, A., Epskamp, S., Eronen, M. I., Hamaker, E., Kuppens, P., Lutz, W., McNally, R. J., Molenaar, P., Tio, P., Voelkle, M. C., & Wichers, M. (2022). Psychopathological networks: Theory, methods and practice. Behaviour Research and Therapy, 149, 104011. https://doi.org/10.1016/j.brat.2021.104011

    van der Wal, J. M., van Borkulo, C. D., Deserno, M. K., Breedvelt, J. J. F., Lees, M., Lokman, J. C., Borsboom, D., Denys, D., van Holst, R. J., Smidt, M. P., Stronks, K., Lucassen, P. J., van Weert, J. C. M., Sloot, P. M. A., Bockting, C. L., & Wiers, R. W. (2021). Advancing urban mental health research: from complexity science to actionable targets for intervention. Lancet Psychiatry, 8(11), 991–1000. https://doi.org/10.1016/s2215-0366(21)00047-x

    Brouwer, M. E., Molenaar, N. M., Burger, H., Williams, A. D., Albers, C., Lambregtse-van den Berg, M., & Bockting, C. L. (2020). Tapering antidepressants while receiving digital Preventive Cognitive Therapy during pregnancy: An experience sampling methodology trial. Frontiers in Psychiatry, 11, 574357. https://doi.org/10.3389/fpsyt.2020.574357

    Holmes, E. A., Ghaderi, A., Harmer, C. J., Ramchandani, P. G., Cuijpers, P., Morrison, A. P., Roiser, J. P., Bockting, C. L., O’Connor, R. C., Shafran, R., Moulds, M. L., & Craske, M. G. (2018). The Lancet Psychiatry Commission on psychological treatments research in tomorrow’s science. The Lancet. Psychiatry, 5(3), 237–286. https://doi.org/10.1016/S2215-0366(17)30513-8

    De Beurs, D., Bockting, C. L., Kerkhof, A., Scheepers, F., O’Connor, R., Penninx, B., & van de Leemput, I. (2020). A network perspective on suicidal behavior: Understanding suicidality as a complex system. Suicide and Life-Threatening Behavior, 0, 1-12. https://doi.org/10.1111/sltb.12676

    Siegle, G. J., Cramer, A. O. J., van Eck, N. J., Spinhoven, P., Hollon, S. D., Ormel, J., . . . Bockting, C. L. (2019). Where are the breaks in translation from theory to clinical practice (and back) in addressing depression? An empirical graph-theoretic approach. Psychological Medicine, 49(16), 2681-2691. https://doi.org/10.1017/s003329171800363x

    Hayes, A. M., Yasinski, C., Ben Barnes, J., & Bockting, C. L. (2015). Network destabilization and transition in depression: New methods for studying the dynamics of therapeutic change. Clinical Psychology Review, 41, 27-39. https://doi.org/10.1016/j.cpr.2015.06.007

Social & Environmental Factors

How does society, our environment and global events influence the onset and maintenance of common mental health disorders?

  • Huth, K., Wal, J. van der, Zavlis, O., Luigjes, J., Lakerveld, J., Galenkamp, H., Lok, A., Stronks, K., Bockting, C. L., Marsman, M., Goudriaan, A., & Holst, R. van. (under review). Individual and neighborhood determinants of depressive symptoms in ethnic minorities in the urban HELIUS sample: A multi-level network perspective. https://doi.org/10.21203/rs.3.rs-4518516/v1

    van der Wal, J. M., Huth, K. B. S., Lok, A., Bockting, C. L., Stronks, K., & Nicolaou, M. (2024). Exploring the mechanisms underlying increased risk of depressive disorder in ethnic minority populations in Europe: A causal loop diagram. Social Science & Medicine, 351, 116977. https://doi.org/10.1016/j.socscimed.2024.116977

    Willemen, F. E. M., Heuschen, C. B. B. C. M., Zantvoord, J. B., Galenkamp, H., de Wit, M. A. S. Zwinderman, A. H., Denys, D. A. J. P., Bockting, C. L., Stronks, L., & Lok, A. (2023). Perceived ethnic discrimination, suicidal ideation and mastery in a multi-ethnic cohort: the HELIUS study. BJPsych Open, 9(1), e21. https://doi.org/10.1192/bjo.2022.640

    Breedvelt, J. J., Tiemeier, H., Sharples, E., Galea, S., Niedzwiedz, C., Elliott, I., & Bockting, C. L. (2022). The effects of neighbourhood social cohesion on preventing depression and anxiety among adolescents and young adults: Rapid review. BJPsych open, 8(4). https://doi.org/10.1192/bjo.2022.57

    Lokman, J. C., & Bockting, C. L. (2022). Pathways to depressive and anxiety disorders during and after the COVID-19 pandemic. Lancet Psychiatry, 9(7), 531–533. https://doi.org/10.1016/S2215-0366(22)00152-

    Fried, E. I., Bockting, C. L.,Arjadi, R., Borsboom, D., Amshoff, M., Cramer, A. O., Epskamp, S.,  Tuerlinckx, F., Carr, D., & Stroebe, M. (2015). From loss to loneliness: The relationship between bereavement and depressive symptoms. Journal of Abnormal Psychology, 124, 256- 265. https://doi.org/10.1037/abn0000028

Neurobiological and Physiological Mechanisms

How does neuro and physiological mechanisms work to cause and maintain common mental health conditions?

  • Chavez-Baldini, U., Nieman, D. H., Keestra, A., Lok, A., Mocking, R. J., De Koning, P., Krzhizhanovskaya, V.V., Bockting, C. L., Van Rooijen, G., Smit, D. J. A., Sutterland, A. L. & Verweij, K. J. H. (2023). The relationship between cognitive functioning and psychopathology in patients with psychiatric disorders: a transdiagnostic network analysis. Psychological Medicine, 53(2), 476-485. https://doi.org/10.1017/S0033291721001781

    Korenblick, V., Korosi, A., Nieuwdorp, M., Bockting, C. L., Brul, S., & Lock, A. (2023). Butyrate’s effects on depressive symptoms and affect in young adults with depression: Study protocol for a pilot randomized controlled trial. Neuroscience Applied, 2(2), 102443. https://doi.org/10.1016/j.nsa.2023.102443

    Krenblik, V., Brouwer, M. E., Korosi, A., Denys, D., Bockting, C. L., Brul, S., & Lok, A. (2023). Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review. Neuropharmacology, 223, 109318. https://doi.org/10.1016/j.neuropharm.2022.109318

    van Kleef, R. S., Marsman, J. C., van Valen, E., Bockting, C. L., Aleman, A., & van Tol, M. J. (2022). Neural basis of positive and negative emotion regulation in remitted depression. NeuroImage. Clinical, 34, 102988. https://doi.org/10.1016/j.nicl.2022.102988

    Cohen, S., Zantvoord, J., Wezenberg, B., Daams, J., Bockting, C. L., Denys, D., & van Wingen, G. (2022). Electroencephalography for predicting antidepressant treatment success: a systematic review and meta-analysis. https://doi.org/10.31234/osf.io/mvnxa

    Cohen, S. E., Zantvoord, J. B., Wezenberg, B. N., Bockting, C. L., & van Wingen, G. A. (2021). Magnetic resonance imaging for individual prediction of treatment response in major depressive disorder: a systematic review and meta-analysis. Translational psychiatry, 11(1), 1-10. https://doi.org/10.1038/s41398-021-01286-x

    Bennebroek Evertsz, F., Sprangers, M. A. G., de Vries, L. M., Sanderman, R., Stokkers, P. C. F., Verdam, M. G. E., Burger, H., & Bockting, C. L. (2020). I am a total failure: Associations between beliefs and anxiety and depression in patients with inflammatory bowel disease with poor mental quality of life. Behavioural and Cognitive Psychotherapy, 48(1), 91-102. https://doi.org/10.1017/s1352465819000444

    Kennis, M., Gerritsen, L., van Dalen, M., Williams, A., Cuijpers, P., & Bockting, C. L. (2020). Prospective biomarkers of major depressive disorder: A systematic review and meta-analysis. Molecular Psychiatry, 25(2), 321-338. https://doi.org/10.1038/s41380-019-0585-z

    Ter Horst, D. M., Schene, A. H., Figueroa, C. A., Assies, J., Lok, A., Bockting, C. L., Ruhé, H., & Mocking, R. J. T. (2019). Cortisol, dehydroepiandrosterone sulfate, fatty acids, and their relation in recurrent depression. Psychoneuroendocrinology, 100, 203-212. https://doi.org/10.1016/j.psyneuen.2018.10.012

    Thesing, C. S., Lok, A., Milaneschi, Y., Assies, J., Bockting, C. L., Figueroa, C. A., Giltay, E. J., Penninx, B. W. J. H., Ruhé, H., Schene, A. H., Bot, M., & Mocking, R. J. T. (2019). Fatty acids and recurrence of major depressive disorder: Combined analysis of two Dutch clinical cohorts. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.13136

    Kennis, M., Gerritsen, L., van Dalen, M., Williams, A., Cuijpers, P., & Bockting, C. L. (2018). T149. Do we have evidence for predictive biomarkers for major depressive disorder? A meta-analysis and systematic review of prospective studies. Biological Psychiatry, 83(9), S186. https://doi.org/10.1016/j.biopsych.2018.02.486

    Bennebroek Evertsz', F., Sprangers, M. A. G., Sitnikova, K., Stokkers, P. C. F., Ponsioen, C. Y., Bartelsman, J. F. W. M., van Bodegraven, A. A., Fischer, S., Depla, A. C. T. M., Mallant, R. C., Sanderman, R., Burger, H., & Bockting, C. L. (2017). Effectiveness of cognitive-behavioral therapy on quality of life, anxiety, and depressive symptoms among patients with inflammatory bowel disease: A multicenter randomized controlled trial. Journal of Consulting  and Clinical Psychology. 85(9), 918-925. https://doi.org/10.1037/ccp0000227

    De Boer, A.G., Bennebroek Evertsz, F., Stokkers, P. C., Bockting, C. L.,Sanderman, R., Hommes, D. W., Sprangers, M. A. & Frings-Dresen, M. H. (2016). Employment status, difficulties at work and quality of life in inflammatory bowel disease patients. European Journal of Gastroenterology & Hepatology, 28(10), 1130-1136.https://doi.org/10.1097/MEG.0000000000000685.

    Assies, J., Mocking, R. J., Lok, A., Koeter, M. W., Bockting, C. L.,Visser, I., Pouwer, F., Ruhé, H.G., & Schene, A. H. (2015). Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for comorbidity with cardiovascular disease. Psychiatry Research, 229, 992-998. https://doi.org/10.1016/j.psychres.2015.06.025

    Mocking, R. J., Pellikaan, C. M., Lok, A., Assies, J., Ruhé, H. G., Koeter, M. W., Visser, I., Bockting, C. L.,Olff, M., & Schene, A. H. (2015). DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence? Psychoneuroendocrinology, 59, 91- 101. https://doi.org/10.1016/j.psyneuen.2015.05.006

    Bockting, C. L.,Mocking, R. J. T., Lok, A., Koeter, M. W. J., & Schene, A. H. (2013). Therapygenetics: The 5HTTLPR as a biomarker for response to psychological therapy? Molecular Psychiatry, 18, 744-745. https://doi.org/10.1038/mp.2012.92

    Lok, A., Bockting, C. L.,Koeter, M. W. J., Snieder, H., Assies, J., Mocking, R. J. T., Vinkers, C. H., Kahn, R. S., Boks, M. P., & Schene, A. H. (2013). Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression. Translational Psychiatry, 3, e288. https://doi.org/10.1038/tp.2013.60

    Mocking, R. J. T., Lok, A., Assies, J., Koeter, M. W. J., Visser, I., Ruhé, H. G., Bockting, C. L.,& Schene, A. H. (2013). Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: Associations with fatty acid concentrations and waist circumference. PLoS ONE,8, e82980. https://doi.org/10.1371/journal.pone.0082980

    Mocking, R.J.T., Ruhé, H.G., Assies, J., Lok, A., Koeter, M.W.J., Visser, I., Bockting, C. L.,& Schene, A.H. (2013). Relationship between the hypothalamic-pituitary-adrenal axis and fatty acid metabolism in recurrent depression. Psychoneuroendocrinology, 38, 1607-1617. https://doi.org/10.1016/j.psyneuen.2013.01.013

Pregnancy and Generational Mental Health

Our lab is interested in investigating common mental health conditions during pregnancy and the post-partum period, as well as how those maternal conditions may impact offspring outcomes.

  • Broeks, C. W., Molenaar, N., Brouwer, M., van den Akker, E. L. T., van Rossum, E. F. C., Van, R., van den Berg, S. A. A., Hillegers, M., Hoogendijk, W. J. G., Burger, H., Bockting, C. L., Kamperman, A. M., & Lambregtse-Van den Berg, M. P. (2023). Intergenerational impact of childhood trauma on hair cortisol concentrations in mothers and their young infants. Comprehensive Psychonuroendocrinology, 14, 100167. https://doi.org/10.1016/j.cpnec.2023.100167

    Franzoi, D., Bockting, C. L., Bennett, K. F., Odom, A., Lucassen, P. J., Pathania, A., Lee, A., Brouwer, M. E., van de Schoot, R., Wiers, R. W., & Breedvelt, J. J. F. (2023). Which individual, social, and urban factors in early childhood predict psychopathology in later childhood, adolescence and young adulthood? A systematic review. SSM - Population Health, 25, 101575. https://doi.org/10.1016/j.ssmph.2023.101575

    Burger, H., Verbeek, T., Aris-Meijer, J. L., Beijers, C., Mol, B. W., Hollon, S. D., OrmeL, J., van Pampus, M., & Bockting, C. L. (2020). Effects of psychological treatment of mental health problems in pregnant women to protect their offspring: Randomised controlled trial. The British Journal of Psychiatry, 216(4), 182-188. https://doi.org/10.1192/bjp.2019.260

    Molenaar, N. M., Brouwer, M. E., Burger, H., Kamperman, A. M., Bergink, V., Hoogendijk, W. J. G., Williams, A., Bockting, C. L., & Lambregtse-van den Berg, M. P. (2020). Preventive cognitive therapy with antidepressant discontinuation during pregnancy: Results from a randomized controlled trial. Journal of Clinical Psychiatry, 81(4). https://doi.org/10.4088/JCP.19l13099

    Molenaar, N. M., Houtman, D., Bijma, H. H., Brouwer, M. E., Burger, H., Hoogendijk, W. J. G., Bockting, C. L., Kampermen, A., & Lambregtse-van den Berg, M. P. (2020). Dose-effect of maternal serotonin reuptake inhibitor use during pregnancy on birth outcomes: A prospective cohort study. Journal of Affective Disorders, 267, 57-62. https://doi.org/10.1016/j.jad.2020.02.003

    Molenaar, N. M., Brouwer, M. E., Kamperman, A. M., Burger, H., Williams, A. D., Hoogendijk, W. J. G., Bockting, C. L., & Lambregtse-van den Berg, M. P. (2019). Recurrence of depression in the perinatal period: Clinical features and associated vulnerability markers in an observational cohort. PLOS One, 14(2), e0212964. https://doi.org/10.1371/journal.pone.0212964

    Molenaar, N. M., Tiemeier, H., van Rossum, E. F. C., Hillegers, M. H. J., Bockting, C. L., Hoogendijk, W. J. G., van den Akker, E., Lambregtse-van den Berg, M. P., & El Marroun, H. (2019). Prenatal maternal psychopathology and stress and offspring HPA axis function at 6 years. Psychoneuroendocrinology, 99, 120-127. https://doi.org/10.1016/j.psyneuen.2018.09.003

    Verbeek, T., Bockting, C. L., Beijers, C., Meijer, J. L., van Pampus, M. G., & Burger, H. (2019). Low socioeconomic status increases effects of negative life events on antenatal anxiety and depression. Women and Birth, 32(1), e138-e143. https://doi.org/10.1016/j.wombi.2018.05.005

    Verbeek, T., Quittner, L., de Cock, P., de Groot, N., Bockting, C. L., & Burger, H. (2019). Personality traits predict meeting the WHO recommendation of 6 months' breastfeeding: A prospective general population cohort study. Advances in Neonatal Care, 19(2), 118-126. https://doi.org/10.1097/anc.0000000000000547

    Brouwer, M. E., Williams, A. D., van Grinsven, S. E., Cuijpers, P., Lambregtse-van den Berg, M. P., Burger, H., & Bockting, C. L. (2018). Offspring outcomes after prenatal interventions for common mental disorders: A meta-analysis. BMC Medicine, 16, 208. https://doi.org/10.1186/s12916-018-1192-6

    Molenaar, N. M., Brouwer, M. E., Duvekot, J. J., Burger, H., Knijff, E. M., Hoogendijk, W. J., Bockting, C. L., de Wolf, G. S., & Lambregtse-van den Berg, M. P. (2018). Antidepressants during pregnancy: Guideline adherence and current practice amongst Dutch gynaecologists and midwives. Midwifery, 61, 29-35. https://doi.org/10.1016/j.midw.2018.02.018

    Beijers, C., Burger, H., Verbeek, T., Bockting, C. L.,& Ormel, J. (2014). Continued smoking and continued alcohol consumption during early pregnancy distinctively associated with personality. Addictive Behaviors, 39, 980-986. https://doi.org/10.1016/j.addbeh.2014.01.022

    Beijers, C., Ormel, J., Meijer, J. L., Verbeek, T., Bockting, C. L.,& Burger, H. (2014). Stressful events and continued smoking and continued alcohol consumption during mid-pregnancy. PloS ONE, 9,e86359. https://doi.org/10.1371/journal.pone.0086359

    Meijer, J. L., Beijers, C., van Pampus, M. G., Verbeek, T., Stolk, R. P., Milgrom, J., Bockting, C. L.,& Burger, H. (2014). Predictive accuracy of Edinburgh Postnatal Depression Scale assessment during pregnancy for the risk of developing postpartum depressive symptoms: A prospective cohort study. BJOG : An International Journal of Obstetrics and Gynaecology, 121, 1604-1610. https://doi.org/10.1111/1471-0528.12759

    Meijer, J. L., Bockting, C. L.,Stolk, R. P., Kotov, R., Ormel, J., & Burger, H. (2014). Associations of life events during pregnancy with longitudinal change in symptoms of antenatal anxiety and depression. Midwifery, 30, 526-531. https://doi.org/10.1016/j.midw.2013.06.008

    Aris-Meijer, J., Bockting, C. L., StolK, R. P., Kotov, R., Ormel, J., & Berger, H. (2013). Associations of life events during pregnancy with longitudinal change in symptoms of antenatal anxiety and depression. Midwifery, 30(5), 526-531. https://doi.org/10.1016/j.midw.2013.06.008

Relapse Factors

Relapse is a common challenge for individuals who have recovered from depression and anxiety. To address this, our lab is dedicated to investigating what factors lead people to relapse in their recovery journey.

  • Besten, M. E., van Vugt, M., Riese, H., Bockting, C. L., Ostafin, B. D., Aleman, A., & van Tol, M.-J. (2024). Understanding mechanisms of depression prevention: Study protocol of a randomized cross-over trial to investigate mechanisms of mindfulness and positive fantasizing as intervention techniques for reducing perseverative cognition in remitted depressed individuals. BMC Psychiatry, 24(1), 141. https://doi.org/10.1186/s12888-024-05592-8

    Breedvelt, J. J. F., Karyotaki, E., Warren, F. C., Brouwer, M. E., Jermann, F., Hollandare, F., Klein, N., de Jonge, M., Klein, D. N., Farb, N., Segal, Z., Biesheuvel Leliefeld, K. E. M., Jarrett, R., Vittengl, J., Thase, M., Ma, H., Kuyken, W., Shallcross, A. J., van Heeringen, C., … Bockting, C. L. (2024). An individual participant data meta-analysis of psychological interventions for preventing depression relapse. Nature Mental Health, 2(2), 154–163. https://doi.org/10.1038/s44220-023-00178-x

    Böttcher, L., Breedvelt, J. J. F., Warren, F. C., Segal, Z., Kuyken, W., & Bockting, C. L. (2023). Identifying relapse predictors in individual participant data with decision trees. BMC Psychiatry, 23(1), 835. https://doi.org/10.1186/s12888-023-05214-9

    Kooiman, B. E., Robberegt, S. J., Albers, C. J., Bockting, C. L., Stikkelbroek, Y. A., & Nauta, M. H. (2023). Congruency of multimodal data-driven personalization with shared decision-making for StayFine: individualized app-based relapse prevention for anxiety and depression in young people. Frontiers in psychiatry, 14, 1229713. https://doi.org/10.3389/fpsyt.2023.1229713

    Robberegt, S. J., Brouwer, M. E., Kooiman, B. E., Stikkelbroek, Y. A., Nauta, M. H., & Bockting, C. L. (2023). Meta-analysis: Relapse prevention strategies for depression and anxiety in remitted adolescents and young adults. Journal of the American Academy of Child & Adolescent Psychiatry, 62(3), 306-317. https://doi.org/10.1016/j.jaac.2022.04.014

    Robberegt, S. J., Kooiman, B. E. A. M., Albers, C. J., Nauta, M. H., Bockting, C. L., & Stikkelbroek, Y. (2023). Personalised app-based relapse prevention of depressive and anxiety disorders in remitted adolescents and young adults: a protocol of the StayFine RCT. BMJ Open 2022; 12:e058560. https://doi.org10.1136/bmjopen-2021-058560

    Teijema, J. J., Hofstee, L., Brouwer, M., de Bruin, J., Ferdinands, G., de Boer, J., Vizan, P., van den Brand, S., Bockting, C. L., van de Schoot, R., & Bagheri, A. (2023). Active learning-based systematic reviewing using switching classification models: The case of the onset, maintenance, and relapse of depressive disorders. Frontiers in Research Metrics and Analytics, 8, 1178181. https://doi.org/10.3389/frma.2023.1178181

    van der Wal, J. M., van Borkulo, C. D., Haslbeck, J. M. B., Slofstra, C., Klein, N. S., Blanken, T. F., Deserno, M. K., Lok, A., Nauta, M. H., & Bockting, C. L. (2023). Differential impact of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment on affect fluctuations and individual affect networks and impact on relapse: A secondary analysis of a randomised controlled trial. eClinicalMedicine, 66.https://doi.org/10.1016/j.eclinm.2023.102329

    van Dis, E. A. M., Bollen, J., Zuidema, W., van Rooij, R., & Bockting, C. L. (2023). ChatGPT: five priorities for research. Nature, 614(7947), 224–226. https://doi.org/10.1038/d41586-023-00288-7

    van Kleef, R., Kaushik, P., Besten, M., Marsman, J., Bockting,  C. L., van Vugt, M., Aleman, A., van Tol, M. (2023). Understanding and predicting future relapse in depression from resting state functional connectivity and self-referential processing. Journal of Psychiatric Research, 165, 305-314. https://doi.org/10.1016/j.jpsychires.2023.07.034

    Breedvelt, J., Brouwer, M. E., Harrer, M., Semkovska, M., Ebert, D. D., Cuijpers, P., & Bockting, C. L. (2021). Psychological interventions as an alternative and add-on to antidepressant medication to prevent depressive relapse: Systematic review and meta-analysis. The British Journal of Psychiatry :The Journal of Mental Science, 219(4), 538–545. https://doi.org/10.1192/bjp.2020.198

    Breedvelt, J., Warren, F. C., Segal, Z., Kuyken, W., & Bockting, C. L. (2021). Continuation of antidepressants vs sequential psychological interventions to prevent relapse in depression: An individual participant data meta-analysis. JAMA Psychiatry, 78(8), 868–875. https://doi.org/10.1001/jamapsychiatry.2021.0823

    Breedvelt, J. J. F., Warren, F. C., Brouwer, M. E., Karyotaki, E., Kuyken, W., Cuijpers, P., van Oppen, P., Gilbody., S. &  Bockting, C. L. (2020). Individual participant data (IPD) meta-analysis of psychological relapse prevention interventions versus control for patients in remission from depression: A protocol. BMJ Open, 10(2), e034158. https://doi.org/10.1136/bmjopen-2019-034158

    Van Tol, M. J., Eike, R., Van Kleef, R., Marsman, J. B., Van Valen, E., Aleman, A., & Bockting, C. L. (2020). P.348 Understanding neurocognitive working mechanisms of relapse prevention – the role of emotion regulation in remitted major depressive disorder. European Neuropsychopharmacology, 40, S202-S203. https://doi.org/10.1016/j.euroneuro.2020.09.264

    Brouwer, M. E., Williams, A. D., Forand, N. R., DeRubeis, R. J., & Bockting, C. L. (2019). Dysfunctional attitudes or extreme response style as predictors of depressive relapse and recurrence after mobile cognitive therapy for recurrent depression. Journal of Affective Disorders, 243, 48-54. https://doi.org/10.1016/j.jad.2018.09.002

    Brouwer, M. E., Williams, A. D., Kennis, M., Fu, Z., Klein, N. S., Cuijpers, P., & Bockting, C. L. (2019). Psychological theories of depressive relapse and recurrence: A systematic review and meta-analysis of prospective studies. Clinical Psychology Review, 74, 101773. https://doi.org/10.1016/j.cpr.2019.101773

    van Kleef, R. S., Bockting, C. L., van Valen, E., Aleman, A., Marsman, J. C., & van Tol, M. J. (2019). Neurocognitive working mechanisms of the prevention of relapse in remitted recurrent depression (NEWPRIDE): Protocol of a randomized controlled neuroimaging trial of preventive cognitive therapy. BMC Psychiatry, 19(1), 409. https://doi.org/10.1186/s12888-019-2384-0

    Bockting, C. L., Klein, N. S., Elgersma, H. J., van Rijsbergen, G. D., Slofstra, C., Ormel, J., Buskens, E., Dekker, J., de Jong, P. J., Nolen, W. A., Schene, A. H., Hollon, S. D., Burger, H. (2018). The effectiveness of preventive cognitive therapy while tapering antidepressants compared with maintenance antidepressant treatment and their combination in the prevention of depressive relapse or recurrence (DRD study): A three-arm randomised controlled trial. Lancet Psychiatry, 5(5), 401-410. https://doi.org/10.1016/S2215-0366(18)30100-7 .

    Klein, N. S., Holtman, G. A., Bockting, C. L., Heymans, M. W., & Burger, H. (2018). Development and validation of a clinical prediction tool to estimate the individual risk of depressive relapse or recurrence in individuals with recurrent depression. Journal of Psychiatric Research, 104, 1-7. https://doi.org/10.1016/j.jpsychires.2018.06.006

    Klein, N. S., Kok, G. D., Burger, H., van Valen, E., Riper, H., Cuijpers, P., Dekker, J., Smit, F., van der Heiden, C., & Bockting, C. L. (2018). No sustainable effects of an internet-based relapse prevention program over 24 months in recurrent depression: Primary outcomes of a randomized controlled trial. Psychotherapy and Psychosomatics, 87(1), 55-57. https://doi.org/10.1159/000485039

    Slofstra, C., Nauta, M. H., Bringmann, L. F., Klein, N. S., Albers, C. J., Batalas, N., Wicher, M., & Bockting, C. L. (2018). Individual negative affective trajectories can be detected during different depressive relapse prevention strategies. Psychotherapy and Psychosomatics, 87(4), 243-245. https://doi.org/10.1159/000489044

    Slofstra, C., Klein, N.S., Nauta, M.H., Wichers, M., Batalas, N., Bockting, C. L. (2017) Imagine your mood: Study design and protocol of a randomized controlled micro-trial using app-based experience sampling methodology to explore processes of change during relapse prevention interventions for recurrent depression. Contemporary Clinical Trials Communications,12(7). https://doi.org/10.1016/j.conctc.2017.07.003.

    Bockting, C. L., Hollon, S. D., Kuyken, W., Jarrett. R., & Dobson, K. S. (2015). A lifetime approach to Major Depressive Disorder: The contributions of psychological interventions in preventing relapse and recurrence. Clinical Psychology Review, 41, 16-26. https://doi.org/10.1016/j.cpr.2015.02.003

    Figueroa, C. A., Ruhé, H. G., Koeter, M., Spinhoven, P., van der Does, W., Bockting, C. L.,& Schene, A. H. (2015). Cognitive reactivity versus dysfunctional cognitions and the prediction of relapse in recurrent major depressive disorder. Journal of Clinical Psychiatry, 76, e1306– e1312. https://doi.org/10.4088/JCP.14m09268

    Van Rijsbergen, G. D., Bockting, C. L.,Burger, H., Spinhoven, P., Koeter, M. W. J., Ruhé, H.  G., Hollon, S. D., & Schene, A. H. (2013). Mood reactivity rather than cognitive reactivity is predictive of depressive relapse: A randomized study with 5.5-year follow-up. Journal of Consulting and Clinical Psychology, 81, 508-17. https://doi.org/10.1037/a0032223

    Van Rijsbergen, G. D., Bockting, C. L.,Berking, M., Koeter, M. W. J., & Schene, A. H. (2012).  Can a one-item mood scale do the trick? Predicting relapse over 5.5-years in recurrent depression. PLoS ONE, 7, e46796. https://doi.org/10.1371/journal.pone.0046796

    Wekking, E. M., Bockting, C. L.,Koeter, M. W. J., & Schene, A. H. (2012). Cognitive functioning in euthymic recurrently depressed patients: Relationship with future relapses and prior course of disease. Journal of Affective Disorders, 141, 300-307. https://doi.org/10.1016/j.jad.2012.03.034

    Beshai, S., Dobson, K. S., Bockting, C. L.,& Quigley, L. (2011). Relapse and recurrence prevention in depression: Current research and future prospects. Clinical Psychology Review, 31, 1349-1360. https://doi.org/10.1016/j.cpr.2011.09.003

    Bockting, C. L., Elgersma, H. J., van Rijsbergen, G. D., de Jonge, P., Ormel, J., Buskens, E., Stant, A. D., de Jong, P. J., Peeters, F. P. M. L., Huibers, M. J. H., Arntz, A., Muris, P., Nolen, W. A., Schene, A. H., & Hollon, S. D. (2011). Disrupting the rhythm of depression: Design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants. BMC Psychiatry, 11, 1.https://doi.org/10.1186/1471-244X-11-8

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